Endoscopy-negative acid reflux disease

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Endoscopy for gastroesophageal reflux disease: choose wisely.

In 2012, a healthy, normal-weight, 61-year-old woman presented to my gastroenterology clinic. She requested endoscopy because she was worried about cancer of the esophagus. Four years earlier, her primary care physician had diagnosed gastroesophageal reflux disease (GERD), prescribed once-daily acid-reduction therapy, and noted complete resolution of symptoms. As a precaution, the primary care ...

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Non-erosive reflux disease (NERD)--acid reflux and symptom patterns.

BACKGROUND Recent reports suggest that patients with non-erosive reflux disease (NERD) treated with anti-reflux medications show lower symptom improvement rates than patients with erosive oesophagitis treated with the same medications. AIM To determine the acid reflux and symptom patterns of patients with NERD in comparison with those with erosive oesophagitis and Barrett's oesophagus, and to...

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Acid inhibition and gastroesophageal reflux disease.

Malfunction of the lower esophageal sphincter results in acid reflux into the esophagus. Reflux is mostly episodic so that the esophagus is not often presented with a continuous acid load. Prediction of esophageal disease related to reflux takes into account the pH of the refluxate and the duration of reflux. Expulsion of the refluxate back into the stomach shortens the time of exposure. The vo...

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Gastro-esophageal reflux and hiatus hernia--endoscopy.

The endoscopic diagnosis of hiatal hernia (sliding type) relies on direct and indirect criteria during the oesophagoscopic or gastroscopic approach. A wide separation between the anatomic and mucosal oesophago-gastric junction, the presence of a so-called Schatzki-ring, a wandering junction with sliding gastric mucosal folds during inspiration and two ringlike structures are important. Whereas ...

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Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease.

BACKGROUND Gastro-oesophageal reflux disease (GORD) - reflux of stomach contents +/- bile into the oesophagus causing symptoms such as heartburn and acid reflux - is a common relapsing and remitting disease which often requires long-term maintenance therapy. Patients with GORD may have oesophagitis (inflammation of the oesophagus) or a normal endoscopy (endoscopy negative reflux disease or ENRD...

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ژورنال

عنوان ژورنال: Alimentary Pharmacology & Therapeutics

سال: 2010

ISSN: 0269-2813

DOI: 10.1111/j.1365-2036.1997.tb00798.x